In recent years, certain chemical safeners also called herbicide antidotec have proved more effective than the associated carbon.
E .g NA (1,8-naphthlic anhydride) is used as seed treatment in maize against EPTC and Butylate @ 0.5 gm per kg of seed.
Examples of Antidotes:
R-25788 –can be tank mixed with EPTC @ 0.6 kg/ha.
CGA -43089, CGA-92194 and MON-4606 can be used against carbamets and chloracetamide herbicides.
The antidotes act inside the plant by either completing with the herbicide molecules for a common site of action or by stimulation their metabolic de-toxification in the protected crop. The environmental factors like, temperature, soil moisture and soil type affect the field performance of antidotes.